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After correction for multiple comparisons, there was a significant interaction between the study group and time for scores on the Stereotypy and Hyperactivity subscales, suggesting that risperidone improved behavior in these areas as well.

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In a Canadian 6-month prospective open-label pilot trial, in which 49 patients with bipolar disorder who were treated with a mood stabilizer and an oral second-generation antipsychotic at baseline were randomized to either continue their respective antipsychotic regimen or to be switches to risperidone LAI, the changeover to injectible risperidone did not cause significant changes in efficacy or safety parameters, indicating its therapeutic equivalence with oral antipsychotic add-on therapies ().

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