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Figures and illustrate the 26 countries in Africa and the foci in the six endemic Latin American countries, respectively, where mass treatment with Mectizan for onchocerciasis is currently indicated and ongoing; the African countries are color-coded to reflect their inclusion in the former Onchocerciasis Control Programme in West Africa (OCP) or African Programme for Onchocerciasis Control (APOC) regions.

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Francis H, Awadzi K, Ottesen EA: The Mazzotti reaction following treatment of onchocerciasis with diethylcarbamazine: clinical severity as a function of infection intensity.

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The inflammation caused by larvae that die in the eye results initially in reversible small opaque spots on the cornea.

The disease is currently estimated to infect more than 120 million people, with more than 40 million incapacitated or disfigured with swelling of the limbs, breasts (lymphoedema) and genitals (hydrocele).

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PCR, ultrasound of the nodules, and sclerocorneal biopsy have also been suggested as other tests to help confirm the diagnosis.

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Much more extensive ulceration was observed in one patient treated in northern Ghana (Awadzi, unpublished observation).

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Consistent with the purposes identified and standards set within this policy and other applicable privacy notices that have been provided, in some cases Merck consolidates and uses personal information that individuals share with Merck through various services and channels, such as the telephone, surveys, Web sites and other online resources and communications, in order to enhance the quality of services that we offer.

Bulletin of the World Health Organization.

Rivas-Alcala AR, Greene BM, Taylor HR, Domiguez-Vazquez A, Ruvalcaba-Macias AM, Lugo-Pfeiffer C, Mackenzie CD, Beltran F: Chemotherapy of onchocerciasis: a controlled comparison of mebendazole, levamisole, and diethylcarbamazine.

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River blindness, also known as onchocerciasis, is a parasitic disease that can cause intense itching, eyesight damage, and irreversible blindness.

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These nodules present concurrently with the development of diffuse papular dermatitis, orange-peel textured skin, linchenified dermatitis, atrophy, fine wrinkles, lymphadenitis ("hanging groin"), and eventually depigmentation (“leopard skin”).

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Ducorps M, Gardon-Wendel N, Ranque S, Ndong W, Boussinesq M, Gardon J, Schneider D, Chippaux JP: Effets secondaires du traitement de la loase hypermicrofilarémique par l'ivermectine.

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Impacts on vector-borne diseases, including malaria, dengue fever, infections by other arboviruses, schistosomiasis, trypanosomiasis, onchocerciasis, and leishmaniasis are reviewed.

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Permission to use any portions of these publications in any manner including posting any portions on a Web site must be obtained by contacting the Merck National Service Center at 1-800-672-6372.

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Modern medicine versus an ancient scourge: progress toward control of onchocerciasis.

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